The 6/110 was launched in late 1961, it was the successor to the Wolseley 6/99. It was a significant revamp of the earlier car, it was endowed with much improved mechanics, the Barrista "Pinin" Farina design, with touches by Sidney Goble, was tinkered with, but was not much different.

Biggest change to the body was the wheelbase increased by 2 inches (51 millimetres), the seating was rearranged to create 3 inches more rear legroom. It used the same engine but was tuned to increase the power from the 6/99’s 102 bhp (76 kW), to a vastly improved 120 bhp (89 kW). The gains in power were achieved with cylinder head and camshaft modifications, as well as the fitting of a new twin bore exhaust system.

For manual transmission cars, the gear lever was moved from the steering column to the floor.  Suspension modifications, included the addition of a transverse shock absorber to counter axle sway. Hydrosteer variable ratio power steering and air conditioning were options from July 1962.

BMC produced 10,800 Mk 1’s at its Crowley plant by 1964 and the Mk ll was launched in May 1964, it came with a 4 speed gearbox, the Borg-Warner overdrive by this time was an optional extra. Other changes included smaller wheels with wider tyres, the fitting of telescopic dampers as opposed to lever arm, thicker disk brakes and another new exhaust system.

BMC became British Leyland in 1968, the Crowley plant had produced 13,301 Wolseley 6/100 cars when production finally ended in March 1968.